Chemistry Department is pleased to host Chemistry and Biochemistry Seminar Series, Tuesday’s at 12:10 pm. Please see Ithaca College Chemistry web page.
Guest Speaker Professor Robert Doyle Ph.D.
of Laura J. and L. Douglas Meredith Professor of Chemistry and Director of Graduate Studies, Syracuse University, NY
will be joining us on Tuesday, October 5th at 12:10 pm will present:
"Peptide design and conjugation in Drug Development for T2DM, Obesity and Cachexia"
Glucagon-like peptide-1 receptor (GLP-1R) agonists used to treat type 2 diabetes mellitus often produce nausea, vomiting, and in some patients, undesired anorexia. Notably, these behavioral effects are caused by direct central GLP-1R activation. I will speak on the creation of a GLP-1R agonist conjugate with modified brain penetrance that enhances GLP-1R-mediated glycemic control without inducing vomiting. Covalent attachment of the GLP-1R agonist exendin-4 (Ex4) to dicyanocobinamide (Cbi), a corrin ring containing precursor of vitamin B12, produces a “corrinated” Ex4 construct (Cbi-Ex4). Data collected in the musk shrew (Suncus murinus), an emetic mammal, reveal beneficial effects of Cbi-Ex4 relative to Ex4, as evidenced by improvements in glycemic responses in glucose tolerance tests and a profound reduction of emetic events. Our findings highlight the potential for clinical use of Cbi-Ex4 for millions of patients.